Patient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation
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چکیده
منابع مشابه
Patient-Derived Tumor Xenografts Are Susceptible to Formation of Human Lymphocytic Tumors1
Patient-derived xenograft (PDX) tumor models have emerged as a new approach to evaluate the effects of cancer drugs on patients' personalized tumor grafts enabling to select the best treatment for the cancer patient and providing a new tool for oncology drug developers. Here, we report that human tumors engrafted in immunodeficient mice are susceptible to formation of B-and T-cell PDX tumors. W...
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چکیده ندارد.
15 صفحه اولPatient-Derived Xenografts in Oncology
Cancer is among the leading causes of death worldwide. In 2012, approximately 14 million new cases and about eight million cancer-related deaths were reported. In the United States, it is estimated that approximately 1,685,210 new cases of cancer will be diagnosed and 595,690 people will die from the disease (www.cancer.gov). Scientists for many years have been investigating cancer biology in a...
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The prognosis of uveal melanoma (UM) remains poor due to a high risk of metastatic disease. No effective therapies have been described for metastatic UM, and new therapies are needed to improve the outcome for these patients. To achieve this goal, new preclinical animal models are needed. Existing animal models, including genetically engineered mice and orthotopic xenograft models in immunodefi...
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Patient-derived xenograft (PDX) models for cancer research have recently attracted considerable attention in both the academy and industry (Hidalgo et al., 2014; Wilding and Bodmer, 2014). PDX models have been developed from different tumor types including lung cancer to improve the drug development process. These models are used for pre-clinical drug evaluation and can be used for the predicti...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2017
ISSN: 0020-7136
DOI: 10.1002/ijc.30561